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Morphine is a drug commonly used in treating moderate to severe pain, such as pain due to cancer, surgery or trauma. Morphine is well absorbed through the gastrointestinal mucosa. However, it undergoes substantial hepatic first-pass effects Therefore, its oral bioavailability is relatively low (~25%). Peak plasma drug concentrations are reached 30 to 90 min after oral administration and 15 to 20 minutes after subcutaneous.
Morphine has a high systemic clearance and an accordingly short half-life of approximately two hours. The primary site of morphine metabolism is the liver, where it undergoes rapid glucuronidation. However, extrahepatic metabolism of the drug can account for up to 30% of its total clearance This extrahepatic metabolism may play a relatively important role in morphine metabolism in patients with severe liver failure.
Important information, (warning)
You should not take morphine if you have asthma or breathing problems, a blockage in your stomach. Morphine can slow or stop your breathing, and may be habit-forming. MISUSE OF THIS MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription.
Taking this medicine during pregnancy may cause life-threatening withdrawal symptoms in the newborn. Fatal side effects can occur if you use this medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing.
Before taking this medicine
You should not take this medicine if you have ever had an allergic reaction to morphine or other narcotic medicines. Do not use morphine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, and others.
Some medicines can interact with morphine and cause a serious condition called serotonin syndrome. Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson’s disease, migraine headaches, serious infections, or prevention of nausea and vomiting. Ask your doctor before making any changes in how or when you take your medications.
If you use morphine while you are pregnant your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born which is very dangerous so beware.
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